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SleepSense™
Melatonin
What to expect from SleepSense:
• Improved, restful sleep
• Reduction of jet lag symptoms
• For those who do shift work
• To reduce the risk of
degenerative disease
• For anti-aging
• Reduces the effects of stress
• Is anti-estrogenic
• Fall asleep faster
• Wake up easier
Melatonin identifi ed in 1958, is a hormone manufactured from
serotonin (our feel good hormone) and secreted by the pineal
gland. The human body is governed by an internal clock that signals
the release of many hormones that regulate various body functions.
Melatonin is most well known for its ability to control our sleep,
wake cycles where it is secreted in darkness and suppressed by the
light.
It is also used to treat jetlag where it resets our internal clock
when we travel by air across several time zones. Children have
much higher melatonin levels than adults and sadly as we age it is
dramatically reduced. Anti-aging specialists believe melatonin to be
essential in retarding the aging process. Low levels of melatonin are
also found in those individuals with sleep and depressive disorders.
ALL FORMULAS ARE MANUFACTURER TESTED AND 3RD PARTY VERIFIED FOR POTENCY
PREFERRED NUTRITION • 153 PERTH STREET, ACTON ONTARIO 888-826-9625 FAX 888-773-7069
Melatonin Protects Against Female Cancers
Exciting new research shows that melatonin is important for much more. A study published
in Neuroendocrinology in 2003 found that melatonin has an antiestrogenic effect on
estrogenreceptor positive breast cancer cells. Further research released in the Journal of the
National Cancer Institute found that nurses who worked rotating night shifts 3 nights per month
for fi fteen years had a higher incidence of colorectal cancer. Earlier studies had confi rmed that
night shift workers had higher rates of breast cancer but the colorectal study found melatonin
also had an anticancer effect on intestinal cancers.
Another study reported in Gynecology and Obstetric Investigation showed a signifi cant
correlation between melatonin defi ciency and endometrial cancer. Unlike cervical cancer there is
no screening method for endometrial cancer which is the most common pelvic cancer in women.
In this study they looked at 138 women. Sixty-eight women were diagnosed with endometrial
cancer and 70 with abnormal bleeding. The researchers compared the blood melatonin levels
of each group and found that there was a 6-fold lower difference in melatonin levels in those
with endometrial cancer. The researchers believe that melatonin levels may be an indicator of
endometrial cancer and declining levels of melatonin a risk factor for developing the disease.
The importance of Vitamin B12
New research shows adding 1000mcg of sublingual B12 makes your melatonin work better.
Those who can’t get to sleep at night may need vitamin B12. Studies show that B12 causes an
earlier release of melatonin at night which resets the sleep-wake cycle. B12 acts directly on the
pineal gland to provoke a faster release of melatonin. Research has also shown that B12 helps
you get to sleep easier and it sensitizes you to morning light, which helps you wake up feeling
refreshed, especially in the elderly who often have sleep problems.
Girgert R, Bartsch C, Hill SM, Kreienberg R, Hanf V. Tracking the elusive antiestrogenic effect of
melatonin: a new methodological approach. Neuroendocrinol Lett. 2003 Dec;24(6):440-4.
Grin W, Grunberger W. A signifi cant correlation between melatonin defi ciency and endometrial
cancer. Gynecol Obstet Invest. 1998;45(1):62-5.
Schernhammer ES, Laden F, Speizer FE, Willett WC, Hunter DJ, Kawachi I, Fuchs CS, Colditz GA.
Night-shift work and risk of colorectal cancer in the nurses’ health study. J Natl Cancer Inst. 2003
Jun 4;95(11):825-8.
PN8353
FORMULA:
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EACH TABLET CONTAINS:
Medicinal Ingredients:
Melatonin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 mg
Vitamin B12 (Methylcobalamin). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1500mcg
NON-MEDICINAL INGREDIENTS: Lactose monohydrate, microcrystalline cellulose, natural
peppermint fl avour, croscarmellose sodium and vegetable grade magnesium stearate
(lubricant).
SUGGESTED USAGE: Put 1 tablet under your tongue to dissolve at bedtime or as directed by
your health care practitioner. Keep out of reach of children.
CAUTION: Not recommended for pregnant or lactating women. Do not use with sedatives
or immunosuppressive drugs. Do not drive or operate machinery for 5 hours after using this
product.
Sealed for your protection and freshness.
This product does not contain artifi cial preservatives, colour or sweeteners; corn, soy,
starch, wheat or yeast.
SleepSense Melatonin is in a sublingual form and it is peppermint fl avored.
SleepSenseTM is a trademark of Preferred Nutrition, Inc.
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